Question

Can I use steroid or antibiotic drops while wearing scleral lenses?

Steroid and antibiotic drops are common for scleral lens wearers, for flares, infections, transplants and after surgery. How they fit around lens wear is a medical decision. Here's what to ask, and what the labels say.

By the Scleral Lens Team · Last reviewed October 2, 2026 · 5 published sources cited

The short answer

Usually not with the lens in, and always on your prescriber's instructions. Most steroid and antibiotic drops go in with the lens out, with a wait before the lens goes back in. Antibiotic labels advise against contact lens wear when you have signs of bacterial conjunctivitis, and with an infection your doctor may want lenses out entirely. Medicine goes inside the lens bowl only when a doctor specifically prescribes it. If you use a steroid drop for more than a short course, expect your eye pressure to be checked.

Key points

  • Your prescriber decides the timing, not the label minimum or a forum.
  • Most medicated drops go in with the lens out, with a wait before insertion.
  • With an eye infection, lenses usually stay out until your doctor clears them.
  • Medicine in the bowl is a prescribed treatment, never a do-it-yourself step.
  • Steroid drops can raise eye pressure, so pressure checks are part of the plan.

Why the prescriber decides

Steroid and antibiotic drops are medicines prescribed for a reason: an infection, inflammation, a transplant, surgery or a flare of eye surface disease. The right timing depends on what’s being treated. A drop used after a healthy routine visit is a different situation from a drop treating an active infection.

So the first answer to “can I wear my lenses?” is always: ask the doctor who prescribed the drop, and tell your fitter. If those are different people, ask them to agree on a plan.

What the labels say

Labels give a starting point, and your prescriber may want something stricter:

  • Pred Forte, a prednisolone steroid suspension, contains benzalkonium chloride. Its label says contact lenses should be removed before using it and may be reinserted 15 minutes after.[1]
  • Lotemax suspension, a loteprednol steroid, also contains benzalkonium chloride, and its label advises patients not to wear soft contact lenses while using it.[2] That wording is about soft lenses; ask your doctor how it applies to your scleral lenses.
  • Vigamox, a moxifloxacin antibiotic, says patients should not wear contact lenses if they have signs or symptoms of bacterial conjunctivitis.[3]

Wearers commonly report doing their medicated drops with the lens out, before insertion or after removal, and that suspensions and preserved drops can leave a sticky film that fogs the lens. Some wait longer than the minimum and rinse the eye with sterile preservative-free saline before the lens goes in.

For how other prescription drops fit around lens wear, see eye drops with scleral lenses.

Drops in the bowl versus over the lens

There are three places a drop can go: over the lens, inside the bowl before insertion, or only when the lens is out. Medicated drops almost always belong in the third group.

Putting medicine inside the bowl holds it against your cornea for hours. Some specialists do prescribe this for specific problems. A review describes one approach for wounds that wouldn’t heal, using antibiotics and steroids in the fluid reservoir during lens wear; even so, an infection developed in 4 of 14 eyes in that report.[4] That’s a prescribed treatment with close follow-up, chosen for a particular eye. It’s never something to try yourself.

Steroids and eye pressure

Steroid eye drops can raise the pressure inside the eye in some people. Pred Forte’s label warns that prolonged use may increase eye pressure in susceptible people, resulting in glaucoma, and that if it’s used for 10 days or longer, eye pressure should be routinely monitored.[1] Lotemax’s label says the same about monitoring pressure if it’s used for 10 days or longer.[2]

So if you’re on a steroid for more than a short course, expect pressure checks, and ask for them if they aren’t happening. Some wearers take steroids long term, for example after a corneal transplant, under regular monitoring. For whether scleral lenses themselves affect eye pressure, see can scleral lenses raise eye pressure and scleral lenses with glaucoma.

When there’s an infection

With a suspected or confirmed infection, many doctors keep the lens out until the eye has healed. Wearers who’ve been through this say they were told to leave the lens out of that eye until cleared, and to replace their case and tools afterward. See scleral lenses after a corneal ulcer.

A risky habit comes up again and again: treating a red, sore eye with leftover antibiotic or steroid drops, or drops bought abroad without an exam. Please don’t. Pred Forte’s label warns that prolonged steroid use may suppress the immune response and increase the hazard of eye infections,[1] and only an exam can tell what’s going on.

What to ask your prescriber

  • Can I wear my lenses during this treatment?
  • How long after each drop before the lens goes in?
  • Should the drop go in only with the lens out?
  • If I’m on a steroid, when will my eye pressure be checked?
  • What signs mean I should stop and call you?

Common questions

My steroid drop is sticky and my lens fogs after it. What helps?

Wearers report that preserved and suspension drops can leave a film. Some wait longer after the drop and rinse the eye with sterile preservative-free saline before insertion. Ask your prescriber how long to wait, and tell your fitter if the fogging continues.

I have leftover steroid or antibiotic drops. Can I use them for a red, sore eye?

No. A red, painful eye in a lens wearer needs to be examined. Steroid labels warn they can increase the risk of eye infections, and the wrong drop can delay the right treatment. Take the lens out and call your eye doctor.

My eye pressure went up on a steroid. Can I keep wearing my lenses?

Ask the doctors managing your pressure and your lenses together. Wearers with steroid-related pressure rises and glaucoma do wear scleral lenses under monitoring, often using pressure drops before insertion or after removal. Don't stop a prescribed drop on your own.

Can my doctor put an antibiotic in my lens bowl?

In some specialist settings, yes, as a prescribed treatment for a specific problem. It's a medical decision with its own risks and close follow-up, not something to do yourself.

Keep reading

Eye drops with scleral lenses

Preservative-free rewetting drops can usually go over the lens during the day. The bowl gets sterile, preservative-free saline unless your fitter tells you to add something. Prescription dry-eye drops, most allergy and redness drops, and milky or oily drops go in with the lens out, timed the way the prescriber or label says. If you're not sure, ask before the drop goes in.

Can you use eye drops with scleral lenses?

Usually, yes, with the right drops in the right place. Preservative-free artificial tears your fitter approves can generally go on top of the lens during the day. Only sterile, preservative-free saline goes in the bowl of the lens, unless your doctor prescribes something else to go there. Prescription drops, including glaucoma drops, are usually timed around lens wear, so ask your fitter and the doctor who prescribed them how to fit them into your day.

Can scleral lenses raise eye pressure?

Possibly, a little, while the lens is on. Some studies in healthy young adults found eye pressure rose during scleral lens wear and returned to baseline after removal, while others found little or no change. Pressure measured after lens removal, including in long-term wearers, has generally been stable. Because these studies are short and mostly in healthy eyes, people with glaucoma or at risk for it should have their optic nerve monitored while wearing scleral lenses.

Can I wear scleral lenses if I have glaucoma?

Often, yes, but it takes planning between your fitter and the doctor who manages your glaucoma. On average, studies find little or no change in eye pressure after scleral lens wear, but almost none were done in people who already have glaucoma, and pressure while the lens is on the eye is hard to measure. Preserved glaucoma drops shouldn't be trapped under the lens, and a filtering bleb or drainage tube usually means a specially shaped lens.

Can I wear scleral lenses after a corneal ulcer?

Often, yes, once the ulcer has fully healed and your eye doctor agrees. A healed ulcer can leave a scar that makes the cornea uneven, and a scleral lens can smooth out that unevenness and improve vision. It can't clear a scar that sits in the center of your vision and blocks light. If the ulcer was linked to contact lens wear, work out with your doctor what went wrong before you go back to any lens, because contact lens use is linked to repeat infections.

Sources

  1. Allergan. Pred Forte (prednisolone acetate ophthalmic suspension), prescribing information. DailyMed. dailymed.nlm.nih.gov
  2. Bausch & Lomb. Lotemax (loteprednol etabonate ophthalmic suspension), prescribing information. DailyMed. dailymed.nlm.nih.gov
  3. Harrow Eye. Vigamox (moxifloxacin hydrochloride ophthalmic solution), prescribing information. DailyMed. dailymed.nlm.nih.gov
  4. Rodriguez-Garcia A, Jimenez-Perez JC, Ruiz-Lozano RE, et al. Scleral lenses and PROSE: indications, complications, and future challenges. Med Hypothesis Discov Innov Ophthalmol. 2025;14(3):73-106. doi:10.51329/mehdiophthal1525 pubmed.ncbi.nlm.nih.gov
  5. U.S. Food and Drug Administration. Contact Lens Risks. Content current as of September 4, 2018. fda.gov

Last updated October 2, 2026. Found an error or a newer study? Let us know and we'll correct the page.